Dissertationsthema:
„Die Role von GARP in der Immunmodulation: von Wundheilung zu Tumorigenesis“
(FB10: Unimedizin Mainz, Hautklinik, Univ.-Prof. Dr. med. Andrea Tüttenberg)
Wissenschaftlicher Werdegang
Since 01/2021
Fast-track PhD in Biology, Dermatology Department, University Medical Center Mainz, Johannes Gutenberg University Mainz, Working group: Prof. Dr. med. Andrea Tüttenberg, Dissertation title: “The role of GARP in immunomodulation: from wound healing to tumorigenesis”
03/2020 – 12/2021
Research Assistant, Dermatology Department, University Medical Center Mainz, Johannes Gutenberg University Mainz, Working group: Prof. Dr. med. Andrea Tüttenberg
09/2019 – 03/2020
Visiting Scientist (Fulbright U.S. Student Program), Dermatology Department, University Medical Center Mainz, Johannes Gutenberg University Mainz, Working group: Prof. Dr. med. Andrea Tüttenberg
03/2019
Cuba Comparative Health Systems Study Abroad (Havana, Cuba), Ohio University
06/2018
Student Lab Assistant, Antibody Production, Quidel Corporation
09/2017 – 05/2019
Student Researcher, Ohio University Honors Tutorial College, Working group: Dr. Ronan Carroll
05/2017 – 08/2017
Student Researcher (DAAD RISE), Dermatology Department, University Medical Center Mainz, Johannes Gutenberg University Mainz, Working group: Prof. Dr. med. Andrea Tüttenberg
06/2016 – 08/2016
Entrepreneurial Lead, Ohio University, I-CORP Ohio
11/2015 – 05/2017
Student Researcher, Ohio University Honors Tutorial College, Working group: Dr. Xiaozhuo Chen
08/2015 – 05/2019
Bachelor of Science (B.Sc.) in Biological Sciences, Ohio University Honors Tutorial College, Thesis title: “Analysis of Intracellular Staphylococcus aureus Enabling Chronic and Recurrent Infections”
06/2014
Service Learning Study Abroad (El Seibo, Dominican Republic), EF Education First
08/2011 – 05/2015
International Baccalaureate Diploma, Dublin Scioto High School, High School Diploma, Dublin Scioto High School
Publikationen
2022
Emily R. Trzeciak, Niklas Zimmer, Peer W. Kämmerer, Daniel Thiem, Bilal Al-Nawas, Andrea Tuettenberg, Sebastian Blatt. GARP Regulates the Immune Capacity of a Human Autologous Platelet Concentrate. Biomedicines. 2022; 10 (12):3136.
Niklas Zimmer, Emily R. Trzeciak, Barbara Graefen, Kazuki Satoh, Andrea Tuettenberg. GARP as a Therapeutic Target for the Modulation of Regulatory T Cells in Cancer and Autoimmunity. Frontiers in Immunology. 2022; 13.
Emily R. Trzeciak, Niklas Zimmer, Isabelle Gehringer, Lara Stein, Barbara Graefen, Jonathan Schupp, Achim Stephan, Stephan Rietz, Michael Prantner, Andrea Tuettenberg. Oxidative Stress Differentially Influences the Survival and Metabolism of Cells in the Melanoma Microenvironment. Cells. 2022; 11 (6):930.
2021
Franziska K. Krebs, Emily R. Trzeciak, Sophia Zimmer, Deniz Özistanbullu, Heidrun Mitzel‐Rink, Markus Meissner, Stephan Grabbe, Carmen Loquai, Andrea Tuettenberg. Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma. Cancer Medicine. 2021; 10 (5):1562-1575.
2019
Emily Trzeciak, Niklas Zimmer, Ella Kim, Jonathan Schupp, Bettina Sprang, Petra Leuke, Fatemeh Khafaji, Florian Ringel, Clemens Sommer, Jochen Tuettenberg, Andrea Tuettenberg. Dual Expression of GARP in Immune and Glioma Cells: Yet Another Mechanism of Cancer Immune Escape. 2019; 1 (2).
Jonathan Schupp, Franziska K. Krebs, Niklas Zimmer, Emily Trzeciak, Detlef Schuppan, Andrea Tuettenberg. Targeting myeloid cells in the tumor sustaining microenvironment. Cellular Immunology. 2019; 343 ():103713.
Rebecca A. Keogh, Rachel L. Zapf, Emily Trzeciak, Gillian G. Null, Richard E. Wiemels, Ronan K. Carroll. Novel Regulation of Alpha-Toxin and the Phenol-Soluble Modulins by Peptidyl-Prolyl cis/trans Isomerase Enzymes in Staphylococcus aureus. Toxins. 2019; 11 (6):343.
Rachel L. Zapf, Richard E. Wiemels, Rebecca A. Keogh, Donald L. Holzschu, Kayla M. Howell, Emily Trzeciak, Andrew R. Caillet, Kellie A. King, Samantha A. Selhorst, Michael J. Naldrett, Jeffrey L. Bose, Ronan K. Carroll. The Small RNA Teg41 Regulates Expression of the Alpha Phenol-Soluble Modulins and Is Required for Virulence in Staphylococcus aureus. Mbio. 2019; 10 (1): e02484-18.
Ausgewählte Konferenzbeiträge
02/2023
49th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung, Innsbruck, Austria
Poster title: “Uncovering the moonlighting function of nuclear GARP in melanoma”
02/2022
48th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung, virtual, poster title: “GARP, a novel driver of proliferation and growth in 2D and 3D cultured melanoma cells”
09/2021
31. Deutscher Hautkrebskongress, virtual, poster title: “Journey to another dimension: the development and application of a 3D melanoma spheroid model”
01/2020 – 02/2020
Arbeitsgemeinschaft Dermatologische Forschung Winter School, Zugspitze, Germany, poster title: “Post-Transcriptional Regulation of GARP Expression in Melanoma and Glioblastoma by miR-142-3p”
04/2019
Ohio University Student Research and Creative Activity Expo, Athens, USA, poster title: “Targeting Staphylococcus aureus infections from the inside-out”
06/2018
62nd Annual Wind River Conference on Prokaryotic Biology, Estes Park, USA, poster title: “Investigating the contribution of the small RNA Teg41 to Staphylococcus aureus infection-related phenotypes”
03/2017
Ohio University Student Research and Creative Activity Expo, Athens, USA, poster title: “ATPase, Ectonucleoside Triphosphate Diphosphohydrolase 2, as a Potential Novel Anticancer Therapeutic”
Stipendien und Auszeichnungen
01/2023
Junior member of the Gutenberg Academy, Johannes Gutenberg University Mainz
03/2021
DAAD One-Year Grants for Doctoral Candidates
04/2019
1st Prize Poster Presentation, Ohio University Student Research and Creative Activity Expo, poster title: “Targeting Staphylococcus aureus infections from the inside-out”
03/2019
Biological Sciences Outstanding Graduating Senior Award, Ohio University Honors Tutorial College
03/2019
Fulbright U.S. Student Program
03/2019
Outstanding Teaching Assistant, Ohio University
11/2018
John J. Kopchick Molecular and Cellular Biology/Translational Biomedical Sciences Undergraduate Student Support Fund, Ohio University
03/2017
DAAD RISE
03/2017
1st Prize Poster Presentation, Ohio University Student Research and Creative Activity Expo, poster title: “ATPase, Ectonucleoside Triphosphate Diphosphohydrolase 2, as a Potential Novel Anticancer Therapeutic”
Lehrveranstaltungen
01/2019 – 05/2019
Teaching Assistant (General Genetics), Ohio University
08/2017 – 12/2017
Teaching Assistant (Introductory Biology), Ohio University
01/2017 – 05/2019
First Aid/CPR/AED Instructor, American Red Cross, Ohio University
Akademisches Engagement
Since 01/2023
Junior member of the Gutenberg Academy, Johannes Gutenberg University Mainz
Since 01/2022
Ada Lovelace Career Orientation Mentorship Program, Johannes Gutenberg University Mainz
Since 06/2021
Mainz Research School of Translational Biomedicine (TransMed), University Medical Center Mainz, Johannes Gutenberg University Mainz
Since 04/2021
German Society for Immunology
Since 03/2020
International Exchange Alumnus, U.S. Department of State Bureau of Educational and Cultural Affairs
Since 09/2015
Beta Beta Beta National Biological Honors Society